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The temperature dependence of the reversible structural relaxation time and diffusion constant of metallic glasses under pressure is theoretically investigated. The compression not only changes the glassy dynamics, but also generates a metastable state along with a higher-energy state where the system can rejuvenate. The relaxation times for forward and backward transitions in this two-state system are nearly identical and much faster than the relaxation time without accounting for barrier recrossing. At ambient pressure, the expected irreversible relaxation process is recovered, and the numerical results agree well with prior experimental results. An increase in pressure has a minor effect on the relaxation time and diffusion constant that one computes without considering the influ... |
Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was aimed to develop hydroxyethyl cellulose (HEC)-based gel containing metronidazole (MTZ) loaded in solid lipid nanoparticles (SLNs), and to enhance the antimicrobial activity of MTZ. SLNs were prepared using a combination method of solvent evaporation and hot homogenization. The results showed that the fabricated SLNs, comprising of Precirol (2.93%, w/v), Tween 80 (1.8%, w/v), and the drug:lipid ratio of 19.3% (w/w), were approximately 200 nm in size, with a narrow distribution. The HEC (3%, ... |
Entrepreneurs play crucial roles in global sustainable development, but limited financial resources constrain their performance and survival rate. Despite the global presence of entrepreneurship, the literature of entrepreneurial finance is suspected to be Western ideologically homogenous. Thus, this study aims at examining this phenomenon by employing the mindsponge mechanism and bibliometric analyses. 412 highly cited publications extracted from the Web of Science database are analyzed to find Western ideological dominance and low tolerance towards heterogeneity in entrepreneurial finance’s core ideologies. The dominance and low tolerance are consistent across author level, institution level, and country level, revealing strong evidence for the existence of Western ideological hom... |
In this work, chaos is experimentally observed from a circuit, in which the nonlinear element is a real memristor. To the best of our knowledge, this is the first nonlinear circuit with a commercially available memristor (KNOWM memristor), which has been implemented in order to experimentally investigate chaos and phenomena related with it, such as a route to chaos via period-doubling, one-scroll and the well-known double-scroll chaotic attractors. |
Alzheimer’s disease (AD) develops into dementia over a period of several years, during which subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) can be used as intermediary diagnoses of increasing severity. Chronic neuroinflammation resulting from insufficient resolution is involved in the pathogenesis of AD and is associated with cognitive impairment |
Retraction notices (RNs) are historical documents and must be as informative as possible to ensure the scholarly record is complete. |
Herein, a library of novel hybrid 6-(4-substituted-1H-1,2,3-triazol-1-yl)-2-mercaptobenzothiazoles was designed using a “left-hand strategy” and synthesized using microwave-assisted synthesis. The synthesized compounds were screened against quorum sensing activities and biofilm formation of Gram-negative bacteria. Biological results reveal that eleven compounds strongly inhibited the quorum sensing activities of the Pseudomonas aeruginosa lasB-gfp reporter strain.Compounds 4g (IC50 of 9.84 ± 1.10 μM), 4h (IC50 of 6.09 ± 0.98 μM), and 4m (IC50 of 12.20 ± 0.25 μM) are 2–5 times stronger than the reference compound 4NPO (IC50 of 32 ± 0.88 μM) in QSI screening. Compounds 4g and 4h inhibited up to 90% of the biofilm formation of Pseudomonas aeruginosa. In terms of anti-virulence effe... |
This paper seeks to introduce a strategy of science communication: Total SciComm or all-out science communication. We proposed that to maximize the outreach and impact, scientists should use different media to communicate different aspects of science, from core ideas to methods. The paper uses an example of a debate surrounding a now-retracted article in the Nature journal, in which open data, preprints, social media, and blogs are being used for a meaningful scientific conversation. The case embodied the central idea of Total SciComm: the scientific community employs every medium to communicate scientific ideas and engages all scientists in the process. |
This paper reports the results of soft computing-based models correlating L and N-type Schmidt hammer rebound numbers of rock. A data-independent database was compiled from available measurements reported in the literature, which was used to train and develop back propagating neural networks, genetic programming and least square method models for the prediction of L-type Schmidt hammer rebound numbers. The results show that the highest predictive accuracy was obtained for the neural network model, which predicts the L type Schmidt hammer rebound number, with less than ±20% deviation from the experimental data for 97.27% of the samples. The optimum neural network is presented as a closed form equation and is also incorporated into an Excel-based graphical user interface, which direct... |
This study describes the willingness of receiving the COVID-19 booster doses for adults and their children 12–17 years old, and its related factors in Vietnam. A cross-sectional study was conducted through a national online survey from November 17 to November 24, 2021 using Google Form. Study respondents were Vietnamese citizens who were ≥18 years old and currently living in Vietnam. A total of 900 complete responses were analyzed and of those 93.77% were willingness to receive the booster dose. Participants with a university degree or higher were 8.16 times higher in willingness than those with primary school (p = .017). Those who received the first or the second dose of the COVID-19 vaccine were 5.85 (p = .001) and 5.65 (p < 0.001) times higher in willingness to receive booster do... |
