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    • Magnolin Enhances Melanogenesis in Melanoma Cells and Three-Dimensional Human Skin Equivalent
    Authors: Takuhiro, Uto; Nguyen, Huu Tung; Tomoe, Ohta; Yukihiro, Shoyama;  Advisor: -;  Co-Author: - (2022)

    Magnoliae Flos is a traditional herbal medicine used to treat nasal congestion associated with headache, empyema, and allergic rhinitis. In our preliminary screening of crude drugs used in Japanese Kampo formulas for melanin synthesis, the methanol extract of Magnoliae Flos was found to exhibit strong melanin synthesis activity. However, there have been no studies evaluating the effects of Magnoliae Flos or its constituents on melanogenesis. The present study aimed to isolate the active compounds from Magnoliae Flos that activate melanin synthesis in melanoma cells and three-dimensional human skin equivalent, and to investigate the molecular mechanism underlying melanin induction. The methanol extract of Magnoliae Flos induced an increase of melanin content in both B16-F1 and HMV-II...
    • Magnolin Enhances Melanogenesis in Melanoma Cells and Three-Dimensional Human Skin Equivalent
    Authors: Takuhiro, Uto; Nguyen, Huu Tung; Tomoe, Ohta; Yukihiro, Shoyama;  Advisor: -;  Co-Author: - (2022)

    Magnoliae Flos is a traditional herbal medicine used to treat nasal congestion associated with headache, empyema, and allergic rhinitis. In our preliminary screening of crude drugs used in Japanese Kampo formulas for melanin synthesis, the methanol extract of Magnoliae Flos was found to exhibit strong melanin synthesis activity. However, there have been no studies evaluating the effects of Magnoliae Flos or its constituents on melanogenesis. The present study aimed to isolate the active compounds from Magnoliae Flos that activate melanin synthesis in melanoma cells and three-dimensional human skin equivalent, and to investigate the molecular mechanism underlying melanin induction. The methanol extract of Magnoliae Flos induced an increase of melanin content in both B16-F1 and HMV-II...