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    • Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea
    Authors: Orfanoudaki, Maria;  Advisor: Hartmann, Anja; Alilou, Mostafa; Mehic, Naida; Kwiatkowski, Marcel; Jöhrer, Karin; Nguyen, Ngoc Hieu; Hensel, Andreas; Greil, Richard; Ganzera, Markus;  Co-Author: - (2021)

    The class of demosponges is the biggest and most diverse of all described sponge species and it is reported to produce a plethora of chemically different metabolites with interesting biological activities. The focus of the present study was to investigate the chemical composition of two Mediterranean demosponges, targeting their brominated compounds and prenylated hydroquinones, compounds with interesting cytotoxic and anti-microbial properties. In order to gain a deeper insight into the chemical diversity of their metabolites and their activities, 20 pure secondary metabolites including new natural products were isolated from two different species (Aplysina aerophoba and Spongia sp.) using various chromatographic techniques. Their structures were confirmed by NMR and HRMS, revealin...