Item Infomation
Title: | Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3- yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents |
Authors: | Do, Thi Mai Dung Eun, Jae Park Duong, Tien Anh Pham, The Hai Le, Quang Bao |
Issue Date: | 2022 |
Publisher: | Bentham Science Publishers |
Abstract: | Herein, we have designed and synthesized a series of the novel (E)-N'-((1-(4-chlorobenzyl)- 1H-indol-3-yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides (5) as potent small molecules activating procaspase- 3. The compounds were designed by the amalgamation of structural features of PAC-1 (the first procaspase-3 activator) and oncrasin-1, one potential anticancer agent |
URI: | https://www.eurekaselect.com/article/120263 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5726 |
Appears in Collections | Bài báo khoa học |
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