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The simultaneous use of drugs with different mechanisms of analgesic action is a strategy for achieving effective pain control while minimizing dose-related side effects. Choline was described to potentiate the analgesic action of parecoxib sodium at small doses in several inflammatory pain models. However, these findings are still very limited, and more associated data are required to confirm the effectiveness of the combined choline and parecoxib sodium therapy against inflammatory pain. |
Unanticipated difficult airway remains a challenge for the anesthesiologist with no established standard criteria to predict difficulty in intubation. Our aim was to correlate the pre-anesthetic ultrasonographic (USG) airway assessment parameters with Cormack-Lehane (CL) grade at direct laryngoscopy view under general anaesthesia. |
This manuscript deals with a Timoshenko system with damping and source. The existence and stability of the solution are analyzed taking into account the competition of the internal damping versus the logarithmic source. We use the potential well theory. For initial data in the stability set created by the Nehari surface, the existence of global solutions is proved using Faedo–Galerkin’s approximation. The exponential decay is given by the Nakao theorem. A numerical approach is presented to illustrate the results obtained. |
This study evaluated programmed cell death-ligand 1 (PD-L1) expression from pre-invasive adenocarcinoma to invasive lung adenocarcinoma, aimed to investigate the potential association of PD-L1 pathway with lung adenocarcinoma early evolution. |
Difficulty in emotion expression and recognition is typical of the personality trait known as alexithymia, which is often observed in persons with neurodevelopmental disorders (NDD). Past research has investigated various forms of conversational technology for people with NDD, but only a few studies have explored the use of conversational agents to reduce alexithymia. This paper presents Emoty, a speech-based conversational agent designed for people with NDD to train emotional communication skills. |
We are interested in the McKay quiver Γ(G) and skew group rings A ∗G, where G is a finite subgroup of GL(V ), where V is a finite dimensional vector space over a field K, and A is a K −G-algebra. These skew group rings appear in Auslander’s version of the McKay correspondence. In the first part of this paper we consider complex reflection groups G⊆GL(V) and find a combinatorial method, making use of Young diagrams, to construct the McKay quivers for the groups G(r,p,n). We first look at the case G(1,1,n), which is isomorphic to the symmetric group Sn, followed by G(r,1,n) for r > 1. |
Many patients with asthma report unmet health care needs. The Patient Needs in Asthma Treatment (NEAT) questionnaire is a validated instrument to quantify these unmet needs. We explored how health professionals evaluated the instrument’s utility as well as patients’ and professionals’ perspectives of how NEAT could be incorporated into routine clinical practice. |
Heterogeneous computing is the major driving factor in designing new energy-efficient high-performance computing systems. Despite the broad adoption of GPUs and other specialized architectures, the interest in spatial architectures like field-programmable gate arrays (FPGAs) has grown. While combining high performance, low power consumption and high adaptability constitute an advantage, these devices still suffer from a weak software ecosystem, which forces application developers to use tools requiring deep knowledge of the underlying system, often leaving legacy code (e.g., Fortran applications) unsupported. |
Cardiopulmonary exercise testing (CPET) is an important clinical tool that provides a global assessment of the respiratory, circulatory and metabolic responses to exercise which are not adequately reflected through the measurement of individual organ system function at rest. In the context of critical COVID-19, CPET is an ideal approach for assessing long term sequelae. |
Immune checkpoint inhibitors (ICIs) have improved outcomes for patients with advanced non-small cell lung cancer (NSCLC) versus chemotherapy in clinical trials. In Germany, ICIs have been used clinically since 2015 for patients with advanced/metastatic NSCLC without epidermal growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) aberrations. As part of I-O Optimise, a multinational research program utilizing real-world data on thoracic malignancies, we describe real-world treatment patterns and survival following reimbursement of ICIs for advanced NSCLC in Germany. |
