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    • Almonertinib-induced interstitial lung disease in a lung adenocarcinoma patient complicated with interstitial lung abnormality
    Authors: Qian, Zhou; Zhong, Hu; Xin, Li;  Advisor: -;  Co-Author: - (2023)

    With the use of targeted drugs in lung cancer patients, targeted drug-induced interstitial lung disease (ILD) has attracted more and more attention. The incidence, time, and severity of different targeted drug-induced ILD vary. Almonertinib/HS-10296 is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Post-marketing safety and effectiveness of almonertinib have been confirmed. The reported adverse events of almonertinib were mainly an increase in creatine phosphokinase, aspartate aminotransferase, and alanine aminotransferase, and onset of rash. Almonertinib-induced ILD is rare.
    • The Minimum Effective Concentration (MEC95) of different volumes of ropivacaine for ultrasound-guided caudal epidural block: a dose-finding study
    Authors: Dongmei, Ma; Yan, Chen; Ping, Chen;  Advisor: -;  Co-Author: - (2023)

    Caudal epidural block (CEB) is a kind of epidural anesthesia in which local anesthesia is injected through the sacral hiatus into the sacral epidural space to block the sacral nerve and temporarily paralyze the area it controls [1]. CEB may be beneficial in anorectal surgery because its use may extend postoperative analgesia, which reduce the need for systemic analgesics and their potential side effects [2, 3]. Although CEB has many clinical applications, it is sometimes difficult to ascertain the anatomical location of the sacral hiatus and the caudal epidural space, particularly in adults [4, 5].
    • Correction: Comparison of analgesic efficacy of different local anesthetic volumes for erector spinae plane block in thoracotomy patients; a prospective randomized trial
    Authors: Musa, Zengin; Hilal, Sazak; Ramazan, Baldemir;  Advisor: -;  Co-Author: - (2023)

    Correctly cite ‘To our knowledge, there are no studies comparing ESPB block applications using different local anesthetic volumes after thoracotomy. However, in a case series with different volumes, it was reported that the block level increased up to 9 dermatomes in a case in which 30 ml of local anesthetic was applied [4]. In studies conducted to determine the optimal level at which volume expansion can be achieved, it has been shown that this volume varies in a wide range such as 2.5 mL/ and 6.6 mL per dermatome, while the median value is 3.4 mL [5]’ should be in the form.