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Results 361-370 of 373 (Search time: 0.005 seconds).
    • Using generalized additive models to decompose time series and waveforms, and dissect heart–lung interaction physiology
    Authors: Johannes, Enevoldsen; Gavin L., Simpson; Simon T., Vistisen;  Advisor: -;  Co-Author: - (2023)

    Common physiological time series and waveforms are composed of repeating cardiac and respiratory cycles. Often, the cardiac effect is the primary interest, but for, e.g., fluid responsiveness prediction, the respiratory effect on arterial blood pressure also convey important information. In either case, it is relevant to disentangle the two effects. Generalized additive models (GAMs) allow estimating the effect of predictors as nonlinear, smooth functions. These smooth functions can represent the cardiac and respiratory cycles’ effects on a physiological signal. We demonstrate how GAMs allow a decomposition of physiological signals from mechanically ventilated subjects into separate effects of the cardiac and respiratory cycles.
    • Disposable laryngoscope intubation to reduce equipment failure in an emergency out of OR setting - a quality control case study
    Authors: Colby G., Simmons; Tobias, Eckle; Dustin, Rogers;  Advisor: -;  Co-Author: - (2023)

    Reusable laryngoscopes have been reported to be superior to disposable laryngoscopes with plastic blades during emergent intubations. Surprisingly, at our institution a quality reporting system revealed a high number of equipment failures with reusable laryngoscopes in an emergency out-of-OR (operating room) setting. As recent studies indicated an improved quality of disposable laryngoscopes, we hypothesized that a thoroughly evaluated disposable laryngoscope would result in less equipment failure in an emergency out-of-OR setting.
    • The rapid detection of respiratory pathogens in critically ill children
    Authors: John A., Clark; Andrew Conway, Morris; Martin D., Curran;  Advisor: -;  Co-Author: - (2023)

    Respiratory infections are the most common reason for admission to paediatric intensive care units (PICU). Most patients with lower respiratory tract infection (LRTI) receive broad-spectrum antimicrobials, despite low rates of bacterial culture confirmation. Here, we evaluated a molecular diagnostic test for LRTI to inform the better use of antimicrobials.
    • Network pharmacology-based mechanism prediction and pharmacological validation of Bushenhuoxue formula attenuating postmenopausal osteoporosis in ovariectomized mice
    Authors: Chenjie, Xia; Haowei, Zhu; Jin, Li; Hongting, Jin;  Advisor: -;  Co-Author: - (2023)

    Postmenopausal osteoporosis (PMOP) is a common bone disorder characterized by low bone mineral density and microstructure deterioration [1]. It is estimated that more than 15% of postmenopausal women over 50 years old are suffering in PMOP worldwide [2]. Most of them have low back pain, hunchback and fragility fractures in different degrees [3]. Although there exist a large amount of anti-osteoporosis drugs such as active vitamin D, estrogen receptor modulators, bisphosphonates and parathyroid hormone [4], various undesirable effects limit their application and efficacy [5]. Natural products and herbs attract increasing attention for their potential anti-osteoporosis effects and relative safety