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  • Authors: Jing, Cai; Yangyang, Wang; Ziqing, Guo;  Advisor: -;  Co-Author: - (2023)

    In this single-centered, randomized controlled study (supplementary Appendix 1), erector spinae plane (ESP) block (Fig. 1) was first attempted for the treatment of critically ill patients with AGI grade II or greater severity. The primary outcomes were the remission and cure rates on days 3 and 7. The remission was defined as a decrease in AGI severity of more than one grade, and cure was defined as the disappearance of AGI symptoms and signs. The secondary outcomes included indicators of gastrointestinal function, inflammation, and clinical outcomes

  • Authors: Rajnish, Kumar; Nishant, Sahay; Shagufta, Naaz;  Advisor: -;  Co-Author: - (2023)

    We present a case of a 60-year-old female, ASA physical status 1, who was posted for sacrocolpopexy for vaginal prolapse. Her all laboratory parameters were within normal limits. She fasted after midnight. General anesthesia was induced using injection midazolam 1 mg, fentanyl 120 μg, propofol 100 mg, and atracurium 30 mg for tracheal intubation. Anesthesia was maintained with oxygen, air, and sevoflurane. Foley’s catheterization was done under an aseptic technique without trauma.

  • Authors: Guo-Liang, Xiao; Yuan, Gao; Hu, Hao;  Advisor: -;  Co-Author: - (2023)

    Surfactants produced by type II alveolar epithelial cells (AT2 cells) are usually present in inclusion organelles called lamellar bodies (LBs). The ATP-binding cassette subfamily A member 3 (ABCA3) transporter primarily exists in AT2 cells and is generally considered to be one of the critical regulators of biogenesis of LBs and surfactant metabolism in the lungs [1,2,3,4]. ABCA3 mutations are the most common cause of congenital surfactant dysfunction disorders (CSDDs), resulting in fatal neonatal respiratory distress and pediatric or adult interstitial lung disease [3, 5,6,7].

  • Authors: Damien, Roux; Nicolas, Benichou; David, Hajage;  Advisor: -;  Co-Author: - (2023)

    Sepsis prognosis correlates with antibiotic adequacy at the early phase. This adequacy is dependent on antibacterial spectrum, bacterial resistance profile and antibiotic dosage. Optimal efficacy of beta-lactams mandates concentrations above the minimal inhibitory concentration (MIC) of the targeted bacteria for the longest time possible over the day. Septic acute kidney injury (AKI) is the most common AKI syndrome in ICU and often mandates renal replacement therapy (RRT) initiation. Both severe AKI and RRT may increase outside target antibiotic concentrations and ultimately alter patient’s prognosis.