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Results 351-360 of 384 (Search time: 0.005 seconds).

Perioperative changes in fluid distribution and haemodynamics in acute high-risk abdominal surgery

Authors: Mirjana, Cihoric; Henrik, Kehlet; Jakob, Højlund; Advisor: -; Co-Author: - (2023)

Understanding the pathophysiology of fluid distribution in acute high-risk abdominal (AHA) surgery is essential in optimizing fluid management. There is currently no data on the time course and haemodynamic implications of fluid distribution in the perioperative period and the differences between the surgical pathologies.

Serum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia

Authors: Yi, Wang; Xiaolan, Huang; Fang, Li; Advisor: -; Co-Author: - (2023)

Community-acquired pneumonia (CAP) is the primary cause of death for children under five years of age globally. Hence, it is essential to investigate new early biomarkers and potential mechanisms involved in disease severity.

General Anesthetics in CAncer REsection Surgery (GA-CARES) randomized multicenter trial of propofol vs volatile inhalational anesthesia protocol description

Authors: Elliott, Bennett-Guerrero; Jamie L., Romeiser; Samuel, DeMaria; Advisor: -; Co-Author: - (2023)

Studies indicate that patients can be “seeded” with their own cancer cells during oncologic surgery and that the immune response to these circulating cancer cells might influence the risk of cancer recurrence. Preliminary data from animal studies and some retrospective analyses suggest that anesthetic technique might affect the immune response during surgery and hence the risk of cancer recurrence. In 2015, experts called for prospective scientific inquiry into whether anesthetic technique used in cancer resection surgeries affects cancer-related outcomes such as recurrence and mortality. Therefore, we designed a pragmatic phase 3 multicenter randomized controlled trial (RCT) called General Anesthetics in Cancer Resectio

A simple-to-use nomogram for predicting prolonged mechanical ventilation for children after Ebstein anomaly corrective surgery: a retrospective cohort study

Authors: Qiao, Liu; Qipeng, Luo; Yinan, Li; Advisor: -; Co-Author: - (2023)

Prolonged mechanical ventilation (PMV) after pediatric cardiac surgery imposes a great burden on patients in terms of morbidity, mortality as well as financial costs. Ebstein anomaly (EA) is a rare congenital heart disease, and few studies have been conducted about PMV in this condition. This study aimed to establish a simple-to-use nomogram to predict the risk of PMV for EA children.

A noval prognostic signature of the N7-methylguanosine (m7G)-related miRNA in lung adenocarcinoma

Authors: Han-ping, Duan; Jian-hui, Yan; Lin, Nie; Advisor: -; Co-Author: - (2023)

Lung adenocarcinoma (LUAD) is characterized by high morbidity and mortality rates and poor prognosis. N7-methylguanosine play an increasingly vital role in lung adenocarcinoma. However, the prognostic value of N7-methylguanosine related-miRNAs in lung adenocarcinoma remains unclear.

Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness an international modified Delphi consensus study evaluation (CONCISE)

Authors: T. W., Davies; R. J. J. van, Gassel; M. van de, Poll; Advisor: -; Co-Author: - (2023)

Clinical research on nutritional and metabolic interventions in critically ill patients is heterogenous regarding time points, outcomes and measurement instruments used, impeding intervention development and data syntheses, and ultimately worsening clinical outcomes. We aimed to identify and develop a set of core outcome domains and associated measurement instruments to include in all research in critically ill patients.

Temporal trends in mortality and provision of intensive care in younger women and men with acute myocardial infarction or stroke

Authors: Ketina, Arslani; Janna, Tontsch; Atanas, Todorov; Advisor: -; Co-Author: - (2023)

Timely management of acute myocardial infarction (AMI) and acute stroke has undergone impressive progress during the last decade. However, it is currently unknown whether both sexes have profited equally from improved strategies. We sought to analyze sex-specific temporal trends in intensive care unit (ICU) admission and mortality in younger patients presenting with AMI or stroke in Switzerland.

The safety and efficacy of mesenchymal stromal cells in ARDS: a meta-analysis of randomized controlled trials

Authors: Fengyun, Wang; Yiming, Li; Bingqing, Wang; Advisor: -; Co-Author: - (2023)

Mesenchymal stromal cells (MSC) have shown potential efficacy in both animal and human trials of acute respiratory distress syndrome (ARDS). Especially during the COVID-19 pandemic, MSC was intensely studied for treating COVID-19-induced ARDS. The purpose of this study is to evaluate the safety and efficacy of MSC in ARDS via a meta-analysis of randomized controlled trials (RCTs). Therefore, a meta-analysis of RCTs of MSC as a therapy for ARDS was conducted. The protocol of this review was registered on Open Science Framework. With no language restriction and according to the “PICOs” principle, searches were conducted on Pubmed and Embase to retrieve any clinical literature on MSC for ARDS. Any RCT, which compared MSC to controls for ARDS, where MSC and controls were intravenously i...

Quality of death after elective surgery: a questionnaire survey for the bereaved family

Authors: Mariko, Sato; Mitsuru, Ida; Yusuke, Naito; Advisor: -; Co-Author: - (2023)

Postoperative death is the third leading cause of death in the world, but the quality of death after surgery has been poorly documented. This study aimed to evaluate the feasibility of a questionnaire survey for the bereaved family regarding the postoperative quality of death and the impact of preoperative functional disability on the quality of death.

Trends in hospital admissions and prescribing due to chronic obstructive pulmonary disease and asthma in England and Wales between 1999 and 2020 an ecological study

Authors: Hassan, Alwafi; Abdallah Y., Naser; Deema Sami, Ashoor; Advisor: -; Co-Author: - (2023)

To investigate the trends in hospital admissions and medication prescriptions related to asthma and chronic obstructive pulmonary disease (COPD) in England and Wales.