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The main complication of intravenous application of recombinant tissue plasminogen activator (rtPA) in acute ischemic stroke is secondary intracerebral hemorrhage (sICH), which occurs in 1.7–8.8% of patients [1, 2], typically in the first 48 h following rtPA administration. It is associated with a mortality rate of up to 70%, mainly due to the mass effect of the hematoma [3]. |