SHANK2 protein contributes to sevoflurane-induced developmental neurotoxicity and cognitive dysfunction in C57BL/6 male mice

Abstract

Repeated exposures to sevoflurane could induce epigenetic modifications in specific brain regions and cognitive impairments in the immature mice. Conflicting findings make neurobehavioral manifestations intricate and potential mechanisms elusive. Influence of neonatal anesthesia with sevoflurane on the expression of synaptic scaffold proteins and neuronal activity remains to be determined.