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dc.contributor.authorSyed M. T., Nasser-
dc.contributor.authorAnas A., Rana-
dc.contributor.authorRainer, Doffinger-
dc.date.accessioned2023-03-21T03:05:17Z-
dc.date.available2023-03-21T03:05:17Z-
dc.date.issued2023-
dc.identifier.urihttps://link.springer.com/article/10.1186/s40635-022-00488-x-
dc.identifier.urihttps://dlib.phenikaa-uni.edu.vn/handle/PNK/7012-
dc.description.abstractDivergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophage Activation Syndrome, which can be driven by elevated Free Interleukin-18 (IL-18) due to failure of negative-feedback release of IL-18 binding protein (IL-18bp). We, therefore, designed a prospective, longitudinal cohort study to examine IL-18 negative-feedback control in relation to COVID-19 severity and mortality from symptom day 15 onwards.vi
dc.language.isoenvi
dc.publisherSpringervi
dc.subjectfree interleukin-18vi
dc.subjectconstant (Kd) of 0.05 nmolvi
dc.titleElevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patientsvi
dc.typeBookvi
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