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    • Current aspects of small extracellular vesicles in pain process and relief
    Authors: Zhang, Lanyu; Liu, Jin; Zhou, Cheng;  Advisor: -;  Co-Author: - (2023)

    Small extracellular vesicles (sEVs) have been identified as a noteworthy paracrine mechanism of intercellular communication in diagnosing and managing neurological disorders. Current research suggests that sEVs play a pivotal role in the pathological progression of pain, emphasizing their critical function in the pathological progression of pain in acute and chronic pain models. By facilitating the transfer of diverse molecules, such as proteins, nucleic acids, and metabolites, sEVs can modulate pain signaling transmission in both the central and peripheral nervous systems. Furthermore, the unique molecules conveyed by sEVs in pain disorders indicate their potential as diagnostic biomarkers. The application of sEVs derived from mesenchymal stem cells (MSCs) in regenerative pain medi...
    • Exosomes derived from mir-214-3p overexpressing mesenchymal stem cells promote myocardial repair
    Authors: Zhu, Wenwu; Wang, Qingjie; Zhang, Jian;  Advisor: -;  Co-Author: - (2023)

    Exosomes are known as nanovesicles that are naturally secreted, playing an essential role in stem-mediated cardioprotection. This study mainly focused on investigating if exosomes derived from miR-214 overexpressing mesenchymal stem cells (MSCs) show more valid cardioprotective ability in a rat model of acute myocardial infarction (AMI) and its potential mechanisms.