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    • Anaplastic lymphoma kinase inhibitor NVP‑TAE684 suppresses the proliferation of human pancreatic adenocarcinoma cells
    Authors: Duong, Hong-Quan;  Advisor: Than, Van Thai; Nguyen, Huyen-Trang; Nguyen, Phuong-Thoa; Ha Thi, Huyen Trang; Bui, Thi Ngoc Ha; Dang, Vu Phuong Linh; Dinh, Thi-Thanh; You, Kyu Sic; Dang, The-Hung; Seong, Yeon-Sun;  Co-Author: - (2021)

    Anaplastic lymphoma kinase (ALK) is known to be an important therapeutic target in various types of cancer. NVP‑TAE684, a well‑known inhibitor of ALK, was revealed to exert antitumor effects in several different malignancies. However, the molecular mechanisms responsible for these antitumor effects in cancer cells, including pancreatic adenocarcinoma cells, remain unknown. In the present study, NVP‑TAE684 was investigated for its antitumor effects towards pancreatic adenocarcinoma cells. MTT assay, western blot analysis, flow cytometry, caspase‑3/7 activity assay and Trypan blue exclusion assay were used and it was revealed that NVP‑TAE684 suppressed the proliferation of seven human p...