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Herein, we demonstrate that 2-difluoromethylpyridine is a bioisosteric replacement of pyridine-N-oxide. Using the quorum sensing inhibitor 4NPO as a model compound, a library of 2-difluoromethylpyridine derivatives was designed, synthesized, and evaluated toward quorum sensing activity, biofilm formation, anti-violacein activity, and protease activity. As a result, compounds 1 (IC50 of 35 ± 1.12 μM), 5 (IC50 of 19 ± 1.01 μM), and 6 (IC50 of 27 ± 0.67 μM) showed a similar or better activity in comparison to 4NPO (IC50 of 33 ± 1.12 μM) in a quorum sensing system of Pseudomonas aeruginosa. In addition, compounds 1, 5, 6, and 4NPO showed good antibiofilm biomass of Pseudomonas aeruginosa ... |
Viện Ngoại giao và An ninh của Học viện Ngoại giao Quốc gia Hàn Quốc xuất bản 「2022 국제정세전망-Triển vọng Tình hình Quốc tế」 vào cuối mỗi năm để đánh giá và dự báo tình hình quốc tế cho năm tiếp theo nhằm đóng góp vào quá trình xây dựng chính sách đối ngoại của chính phủ và giúp quần chúng hiểu biết về tình hình quốc tế.
"Triển vọng tình hình quốc tế năm 2022" bao gồm lời nói đầu của Hong Hyeon-ik thuộc Học viện Ngoại giao Quốc gia và bốn chương: tình hình trên Bán đảo Triều Tiên, tình hình ở các nước lớn, tình hình theo khu vực và các vấn đề toàn cầu và quản trị.
Nội dung của tập sách này được viết với tư cách là tài liệu tham khảo cho việc triển khai chính sách ngoại giao quốc g... |
Ⅰ. 남북관계
1. 남북대화
2. 남북 교류·협력
3. 한반도 비핵화
4. 남북 군사관계
5. 평화·통일 국민공감대
Ⅱ. 북한 정세
1. 정치
2. 군사
3. 경제
4. 대남·대외
5. 사회문화
Ⅲ. 국제 정세
1. 동북아 질서
2. 미국
3. 중국
4. 일본
5. 러시아
Ⅳ. 인권·인도주의
1. 북한인권
2. 이산가족·대북인도지원
3. 남북 인도주의협력 |
A New York Times analysis, based on research from Harvard Law School, Columbia Law School and other sources, counts more than 90 environmental rules and regulations rolled back under Mr. Trump. |
Child maltreatment remains a major health threat globally that requires the understanding of socioeconomic and cultural contexts to craft effective interventions. However, little is known about research agendas globally and the development of knowledge-producing networks in this field of study. This study aims to explore the bibliometric overview on child maltreatment publications to understand their growth from 1916 to 2018. Data from the Web of Science Core Collection were collected in May 2018. Only research articles and reviews written in the English language were included, with no restrictions by publication date. We analyzed publication years, number of papers, journals, authors... |
Recently, Asia has emerged as a new hub of international students, apart from the traditional hosts such as North America, Europe or Australia. Along with this phenomenon, there has been increasing international education scholars selecting international student mobilities in Asia as objects of research. Nevertheless, there has not yet any systematic knowledge about the existing literature on international student mobilities in Asia-related studies. This project aims to fulfil this void by analyzing data obtained from Scopus dataset from 1984 to 2019. Using descriptive statistics as well as advanced bibliometric analyses, the review identified influential documents, topics, sources wh... |
The mental health of university students is not only a predominant topic for psychology and education researchers but also a source of interest for policymakers and various stakeholders. Although there has been a lot of research on higher education students’ mental health, we have little understanding on the mental health of international students (MHIS). Despite their distinctive characteristics compared to native students, the mental health issues of international students only started receiving attention very recently. So far, the literature on this topic lacks a comprehensive overview of its sub-topic and trending issues. By using bibliometric analysis, this research aims to fulfi... |
The mental health of university students is not only a predominant topic for psychology and education researchers but also a source of interest for policymakers and various stakeholders. Although there has been a lot of research on higher education students’ mental health, we have little understanding on the mental health of international students (MHIS). Despite their distinctive characteristics compared to native students, the mental health issues of international students only started receiving attention very recently. So far, the literature on this topic lacks a comprehensive overview of its sub-topic and trending issues. By using bibliometric analysis, this research aims to fulfi... |
This study adopts the bibliometric approach to identify the key characteristics in the relationship of demographic factors (age, gender, affiliations, and locations), scientific productivity, and the collaboration among development economics researchers in Vietnam during the period 2008–2020. Overall, the number of publications and authors in development economics are rising steeply with the average annual growth rate of nearly 23% and 26%, respectively. Moreover, the ‘quality’ of the research appears to be high as 59% of the articles are published in journals in the first and second quartile according Scimago journal ranking. However, the citation counts for these studies indicate th... |
This study adopts the bibliometric approach to identify the key characteristics in the relationship of demographic factors (age, gender, affiliations, and locations), scientific productivity, and the collaboration among development economics researchers in Vietnam during the period 2008–2020. Overall, the number of publications and authors in development economics are rising steeply with the average annual growth rate of nearly 23% and 26%, respectively. Moreover, the ‘quality’ of the research appears to be high as 59% of the articles are published in journals in the first and second quartile according Scimago journal ranking. However, the citation counts for these studies indicate th... |
"A Byte of Python" is a free book on programming using the Python language. It serves as a tutorial or guide to the Python language for a beginner audience. If all you know about computers is how to save text files, then this is the book for you. |
Climate change is a global threat, and inhalational anesthetics contribute to global warming by altering the photophysical properties of the atmosphere. On a global perspective, there is a fundamental need to reduce perioperative morbidity and mortality and to provide safe anesthesia. Thus, inhalational anesthetics will remain a significant source of emissions in the foreseeable future. It is, therefore, necessary to develop and implement strategies to minimize the consumption of inhalational anesthetics to reduce the ecological footprint of inhalational anesthesia. |
Glossopharyngeal neuralgia is a condition that causes severe pain in the throat during swallowing. Although carbamazepine is a viable option for treating glossopharyngeal neuralgia, there are minimal data regarding the effect of alternative agents to treat it. We report on glossopharyngeal neuralgia, which is successfully controlled by levetiracetam. |
The lingual nerve is a branch of the mandibular nerve which is a branch of the trigeminal nerve and provides general sensation to the anterior two-thirds of the tongue, and this nerve lies deep to the hyoglossus muscle (Dotiwala and Samra 2018). |
Landslide susceptibility maps (LSMs) are very crucial for planning policies in hazardous areas. However, the accuracy and reliability of LSMs depend on available data and the selection of suitable methods. This study is conducted to produce LSMs by combinations of machine learning methods and weighting techniques for Ha Giang province, Vietnam, where has limited data. In study area, we gather 11 landslide conditioning factors and establish a landslide inventory map. Computing the weights of classes (or factors) is very important to prepare data for machine learning methods to generate LSMs. We first use frequency ratio (FR) and analytic hierarchy process (AHP) techniques to generate t... |
Landslide susceptibility maps (LSMs) are very crucial for planning policies in hazardous areas. However, the accuracy and reliability of LSMs depend on available data and the selection of suitable methods. This study is conducted to produce LSMs by combinations of machine learning methods and weighting techniques for Ha Giang province, Vietnam, where has limited data. In study area, we gather 11 landslide conditioning factors and establish a landslide inventory map. Computing the weights of classes (or factors) is very important to prepare data for machine learning methods to generate LSMs. We first use frequency ratio (FR) and analytic hierarchy process (AHP) techniques to generate t... |
In this paper, we numerically investigate the dynamics of a compound droplet driven by surface tension variation induced by a thermal gradient in a sinusoidal constriction tube. Initially, the compound droplet with a concentric inner core is spherical and placed in the constriction's upstream region at a low temperature. As time progresses, it migrates downstream with a high temperature. Due to the constriction, the droplet is slowed down in the upstream region and accelerated again right after passing the constriction. This acceleration maximizes the eccentricity. However, the constriction results in an increase in the maximum eccentricity when increasing its depth to a value corresp... |
In this paper, we numerically investigate the dynamics of a compound droplet driven by surface tension variation induced by a thermal gradient in a sinusoidal constriction tube. Initially, the compound droplet with a concentric inner core is spherical and placed in the constriction's upstream region with a low temperature. As time progresses, it migrates to the downstream with a high temperature. Due to the constriction, the droplet is slowed down in the upstream region and accelerated again right after passing the constriction. This acceleration maximizes the eccentricity. However, the constriction results in an increase in the maximum eccentricity when increasing its depth to a valu... |