Tìm kiếm theo: Chủ đề Cancer
Kết quả [1 - 3] / 3
In his now classic writings on the origin of cancer, Sir Richard Doll1 proposed 3 potential causative factors underlying tumor development: (1) environmental factors, particularly diet, industrial pollution, and viruses; (2) systemic factors, including breakdowns in immunosurveillance; and (3) genetic factors, such as the degree of susceptibility to cancer. Since Doll’s publications in the late 1970s, the biology underlying these proposed causative factors—which were derived largely from epidemiological studies—has been carefully scrutinized to determine the causes of cancer at the biochemical, cellular, and molecular levels. Because
of the intensity of biological research and the ra... |
Chemo-resistance has pushed cancer treatment to the boundary of failure. This challenge has encouraged scientists to look for nanotechnological solutions. In this study, we have taken this goal one step further without depending on chemotherapy. Specifically, hybrid metal, polymer, and lipid nanoparticles that formed an IR780-a photosensitizer and Zinc copper oxide incorporated nanoparticle (ZCNP) nanoparticles were utilized in a combined photothermal and photodynamic therapy. Through the mediation of triphenylphosphonium (TPP) as a mitochondria-targeting moiety, TPP-conjugated polymer-lipid hybrid nanoparticles containing ZCNP/IR-780 significantly enhanced cellular uptake by cancer c... |
