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Browsing by Subject X-ray crystallography

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    • Crystal structure of Type IX secretion system PorE C-terminal domain from Porphyromonas gingivalis in complex with a peptidoglycan fragment
    Authors: Nhung Thi Trang Trinh; Hieu Quang Tran; Quyen Van Dong; Christian Cambillau; Alain Roussel; Philippe Leone;  Advisor: -;  Co-Author: - (2021)

    Porphyromonas gingivalis, the major human pathogen associated to periodontal diseases, utilizes the Bacteroidetes-specific type IX secretion system (T9SS) to export virulence factors. PorE is a periplasmic multi-domain lipoprotein associated to the outer membrane that was recently identified as essential for T9SS function. Little is known on T9SS at the structural level, and in particular its interaction with peptidoglycan. This prompted us to carry out structural studies on PorE full length as well as on its four isolated domains. Here we report the crystal structure of the C-terminal OmpA_C-like putative peptidoglycan-binding domain at 1.55?� resolution. An electron density volume w...