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Hoàng Vương Quân (39)
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Browsing by Subject randomized controlled trial

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Intravenous vitamin C monotherapy in critically ill patients a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

Authors: Zheng-Yii, Lee; Luis, Ortiz-Reyes; Charles Chin Han, Lew; Advisor: -; Co-Author: - (2023)

A recent landmark randomized controlled trial (RCT) in septic patients demonstrated an increased risk of death and persistent organ dysfunction with intravenous Vitamin C (IVVC) monotherapy, which represents a disparate result from previous systematic reviews and meta-analyses (SRMA). We performed an updated SRMA of IVVC monotherapy to summarize and explore heterogeneity across current trials and conduct trial sequential analysis (TSA) to guard against type-I or type-II statistical errors.