DUYỆT THEO

HỒ SƠ TÁC GIẢ

Tìm kiếm theo: Tác giả Chen, Huei-Jen

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Hoặc nhập chữ cái đầu tiên:  
Kết quả [1 - 1] / 1
    • Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20)
    Tác giả : Chen, Huei-Jen; Cheng, Yi-An; Chen, Yu-Tung;  Người hướng dẫn: -;  Đồng tác giả: - (2023)

    PEGylated nanoparticles (PEG-NPs) are not effective for hematologic malignancies as they lack the enhanced permeability and retention effect (EPR effect). Tumor-targeted PEG-NPs can systemically track lymphoma and actively internalize into cancer cells to enhance therapeutic efficacy. We generated an anti-PEG bispecific antibody (BsAb; mPEG × CD20) which was able to simultaneously bind to methoxy PEG on liposomes and CD20 to form multivalent αCD20-armed liposomes. This αCD20-armed liposome was able to crosslink CD20 on lymphoma cells to enhance cellular internalization and the anti-cancer efficacy of the liposomes to lymphoma. We generated mPEG × CD20 and used this bispecific antibody...