DUYỆT THEO

HỒ SƠ TÁC GIẢ

Tìm kiếm theo: Tác giả Gao, You

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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    • Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species
    Tác giả : Yin, Hanying; Gao, You; Chen, Weiguang;  Người hướng dẫn: -;  Đồng tác giả: - (2023)

    Adverse skin reactions caused by ionizing radiation are collectively called radiation dermatitis (RD), and the use of nanomedicine is an attractive approach to this condition. Therefore, we designed and large-scale synthesized fullerenols that showed free radical scavenging ability in vitro. Next, we pretreated X-ray-exposed cells with fullerenols. The results showed that pretreatment with fullerenols significantly scavenged intracellular reactive oxygen species (ROS) produced and enhanced the antioxidant capacity, protecting skin cells from X-ray-induced DNA damage and apoptosis. Moreover, we induced RD in mice by applying 30 Gy of X-ray irradiation, followed by treatment with fuller...