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    • Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-κB activation
    Authors: Ngoc Khanh Pham; Huu Tai Bui; Thu Huong Tran; Thi Ngoc Anh Hoang; Thi Ha Vu; Dinh Tung Do; Young Ho Kim; Seok Bean Song; Dao CuongTo; Manh Cuong Nguyen;  Advisor: -;  Co-Author: - (2021)

    Dysoxylum tpongense Pierre (local name ‘Huynh Dan Bap’) belonging to family Meliaceae, is a tree (3–10 m height), distributed in the mountainous areas (ca. 1000 m a.s.l.) in North Vietnam. From the dichloromethane fraction of the methanol extract of the leaves and stems of this plant, six dammarane triterpenes, one furanoid diterpene together with three sterols were isolated. Evaluation of biological activities of isolated compounds showed that cabraleahydroxylactone (5), cabraleahydroxylactone 3-acetate (6), and stigmast-4-en-3-one (10) possessed an anti-inflammatory effect against Liver X receptor (LXR) activation in HepG2 cell line model with IC50 values of 20.29 ± 3.69, 24.32 ± 2....