Item Infomation

Title: pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials
Authors: Trong Bien Tran
Advisor: Tuan Hiep Tran
Yen Hai Vu
Thien Giap Le
Thao Thi Do
Nga Thi Nguyen
Thuan Thi Nguyen
Tung Bao Pham
Trung Quang Ngo
Quang Anh Luong
Chien Ngoc Nguyen
Issue Date: 2021
Publisher: Cellulose
Abstract: Ethyl cellulose (EC) is widely used in the pharmaceutical field as a polymeric excipient to fabricate sustained-release drug delivery systems. To develop a controlled release carrier exploiting the unique characteristic acidic environment of the target tumor site, this study examined the use of EC and lecithin (LC) as a nanoparticulated system. Paclitaxel and dihydroartemisinin were used as model drug combinations. The optimized formulated nanoparticles (NPs) of EC (EC NPs) and EC/LC (EC/LC NPs) were spherical and approximately 130 nm in diameter as determined by dynamic light scattering and electron microscopy analyses. The in vitro drug release from EC/LC NPs exhibited a pH-dependent pattern. In in vitro cell studies, the NPs were taken up by cells, and cell growth was inhibited by drugs released from the formulations. Most importantly, the in vivo anti-tumor study in mice showed a significant reduction in tumor volume after the intravenous administration of EC/LC NPs, suggesting the potential of using EC and LC as controlled and pH-sensitive drug delivery carriers.
Description: Q1
Appears in CollectionsBài báo khoa học




Files in This Item:
  • 10.1007@s10570-021-03769-y.pdf
      Restricted Access
    • Size : 1,9 MB

    • Format : Adobe PDF