Item Infomation
Title: | Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria |
Authors: | Truong Thanh Tung Thang Nguyen Quoc |
Issue Date: | 2021 |
Publisher: | Bioorganic & Medicinal Chemistry Letters |
Abstract: | To date, a very limited number of peptides reported as quorum sensing inhibitors. Herein, we report the synthesis and evaluation of a series of β-turn mimetic-based peptides as potent quorum sensing inhibitors and antibiofilm formation. In this series, peptides P1, P4, and P5 showed very promising anti-quorum sensing activity on lasB-gfp reporter strain of Pseudomonas aeruginosa without affecting bacterial growth. Under our condition, these compounds also showed good anti-violacein production of Chromobacterium violaceum. In terms of antibiofilm formation, except P5, two β-turn mimetic-based peptides P1 and P4 showed maximum inhibition of 80% total biomass of Pseudomonas aeruginosa. This report provides the first β-turn mimetic-based scaffold for future drug development. |
URI: | https://www.sciencedirect.com/science/article/abs/pii/S0960894X21003978?via%3Dihub https://dlib.phenikaa-uni.edu.vn/handle/PNK/2814 |
Appears in Collections | Bài báo khoa học |
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