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Chemo-resistance has pushed cancer treatment to the boundary of failure. This challenge has encouraged scientists to look for nanotechnological solutions. In this study, we have taken this goal one step further without depending on chemotherapy. Specifically, hybrid metal, polymer, and lipid nanoparticles that formed an IR780-a photosensitizer and Zinc copper oxide incorporated nanoparticle (ZCNP) nanoparticles were utilized in a combined photothermal and photodynamic therapy. Through the mediation of triphenylphosphonium (TPP) as a mitochondria-targeting moiety, TPP-conjugated polymer-lipid hybrid nanoparticles containing ZCNP/IR-780 significantly enhanced cellular uptake by cancer cells and selectively targeted the mitochondria, which improved the induction of apoptosis. In tumor-... |
We show that the canonical seesaw mechanism implemented by the
U
(
1
)
B
−
L
gauge symmetry provides two-component dark matter naturally. The seesaw scale that breaks
B
−
L
defines a residual gauge symmetry to be
Z
6
=
Z
2
⊗
Z
3
, where
Z
2
leads to the usual matter parity, while
Z
3
is newly recognized, transforming quark fields nontrivially. The dark matter components—that transform nontrivially under the matter parity and
Z
3
, respectively—can gain arbitrary masses, despite the fact that the
Z
3
dark matter may be heavier than the light quarks
u
,
d
. This dark matter setup can address the XENON1T anomaly recently observed and other observables, given that the dark matter masses are nearly degenerate, heavier than the electron a... |
Ethyl cellulose (EC) is widely used in the pharmaceutical field as a polymeric excipient to fabricate sustained-release drug delivery systems. To develop a controlled release carrier exploiting the unique characteristic acidic environment of the target tumor site, this study examined the use of EC and lecithin (LC) as a nanoparticulated system. Paclitaxel and dihydroartemisinin were used as model drug combinations. The optimized formulated nanoparticles (NPs) of EC (EC NPs) and EC/LC (EC/LC NPs) were spherical and approximately 130 nm in diameter as determined by dynamic light scattering and electron microscopy analyses. The in vitro drug release from EC/LC NPs exhibited a pH-dependent pattern. In in vitro cell studies, the NPs were taken up by cells, and cell growth was inhibited b... |
Threshold switching devices are fundamental active elements in more than Moore approaches, integrating the new generation of non-volatile memory devices. Here, the authors report an in-plane threshold resistive switching device with an on/off ratio above 106, a low resistance state of 10 to 100 kΩ and a high resistance state of 10 to 100 GΩ. Our devices are based on nanocomposites of silver nanowire networks and titanium oxide, where volatile unipolar threshold switching takes place across the gap left by partially spheroidized nanowires. Device reversibility depends on the titanium oxide thickness, while nanowire network density determines the threshold voltage, which can reach as low as 0.16 V. The switching mechanism is explained through percolation between metal–semiconductor is... |
Orange-red-emitting Eu3+-doped Ca9Gd(PO4)7 phosphors have been obtained by a sol-gel technique. These phosphors, excited by UV (270 nm) and near UV light (394 nm), emit orange-red light in the range of 580–710 nm. The Ca9Gd(PO4)7:7 mol% Eu3+ phosphor annealed at 1100 °C shows the highest PL intensity. Judd-Ofelt analysis reveals that the neighbor surroundings of Eu3+ ions are asymmetric, and the lowest asymmetry value is found at the dopant ratio of 7 mol%. The optimal phosphor excited by the wavelength of 394 nm displays an excellent thermal stability (∼76.4 % at 160 °C) with an activation energy of 0.163 eV. The corresponding CIE chromaticity coordinates (x; y) and color purity are calculated to be (0.5849; 0.3635) and 84.6 %, respectively. The quantum efficiency values of the Ca9... |
In magnetic resonance imaging (MRI), the scan time for acquiring an image is relatively long, resulting in patient uncomfortable and error artifacts. Fortunately, the compressed sensing (CS) and parallel magnetic resonance imaging (pMRI) can reduce the scan time of the MRI without significantly compromising the quality of the images. It has been found that the combination of pMRI and CS can better improve the image reconstruction, which will accelerate the speed of MRI acquisition because the number of measurements is much smaller than that by pMRI. In this paper, we propose combining a combined CS method and pMRI for better accelerating the MRI acquisition. In the combined CS method, the under-sampled data of the K-space is performed by taking both regular sampling and traditional ... |
The energy demand has recently been increasing dramatically; thus, it is evident that scientists worldwide need to find out the solution to solve the above problem. Among these technologies, solar and wind power energy are the most potential source as alternatives to fossil fuels. However, these energy sources are not continuous and are therefore considered as additional sources. A regenerative fuel cell (RFC) is a type of fuel cell that can function as an electrolyzer and fuel cell; therefore, this system is an independent power source and overcome the drawbacks of the original fuel cell system. This research has built a system to control the entire regenerative fuel cell system's flow, temperature, and energy. The system uses electricity to produce hydrogen and oxygen for storage;... |
Magnetic field of rotating pulsar might be so strong that the equation of state (EOS) of neutron star (NS) matter is significantly affected by the spin polarization of baryons. In the present work, the EOS of the spin-polarized nuclear matter is investigated in the nonrelativistic Hartree-Fock formalism, using a realistic density dependent nucleon-nucleon interaction with its spin and spin-isospin dependence accurately adjusted to the Brueckner-Hartree-Fock results for the spin-polarized nuclear matter. The nuclear symmetry energy and proton fraction are found to increase significantly with the increasing spin polarization of baryons, leading to a larger probability of the direct Urca process in the cooling of magnetar. The EOS of the β-stable npeμ matter obtained at different spin ... |
The application of S2R strategies in English reading comprehension by university students in Vietnam Reading plays a significantly important role in every student’s academic development, especially when they have to work over a great number of foreign language materials for their professional subjects (McDonough & Shaw, 2013). Strengthening English reading ability is necessary for students to promote individual ability in university education. One of the most important factors affecting students’ English reading proficiency is their use of reading strategies. This study is taken to explore how Vietnamese university students applied Self-strategic regulation (S2R) strategies in their English reading comprehension. 963 students from 6 universities in the North of Vietnam participated in the study. The results of the study through the questionnaire and semi-sructured intreviews show t... |
In this paper, we extend our investigation of the validity of the cosmic no-hair conjecture within non-canonical anisotropic inflation. As a result, we are able to figure out an exact Bianchi type I solution to a power-law {\it k}-inflation model in the presence of unusual coupling between scalar and electromagnetic fields as −f2(ϕ)FμνFμν/4. Furthermore, stability analysis based on the dynamical system method indicates that the obtained solution does admit stable and attractive hairs during an inflationary phase and therefore violates the cosmic no-hair conjecture. |
