Item Infomation
Title: | Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature |
Authors: | Truong Thanh. Tung John Nielsen |
Issue Date: | 2021 |
Publisher: | Royal Society of Chemistry |
Abstract: | Herein, we report a green, expeditious, and practically simple protocol for direct coupling of carboxylate salts and ammonium salts under ACN/H2O conditions at room temperature without the addition of tertiary amine bases. The water-soluble coupling reagent EDC·HCl is a key component in the reaction. The reaction runs smoothly with unsubstituted/substituted ammonium salts and provides a clean product without column chromatography. Our reaction tolerates both carboxylate (which are unstable in other forms) and amine salts (which are unstable/volatile when present in free form). We believe that the reported method could be used as an alternative and suitable method at the laboratory and industrial scales |
Description: | 19, 10073-10080 |
URI: | https://dlib.phenikaa-uni.edu.vn/handle/PNK/4010 |
Appears in Collections | Bài báo khoa học |
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