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    • Antimicrobial Properties of Distichochlamys citrea M.F. Newman Rhizome n -Hexane Extract against Streptococcus pyogenes : Experimental Evidences and Computational Screening
    Authors: Dr. Nguyen Van Hue; Dr. To Dao Cuong; Dr. Phan Tu Quy;  Advisor: -;  Co-Author: - (2022)

    Distichochlamys citrea is an endemic plant species found only in Vietnam, known by folk medicine as a natural antibiotic source. Experimental evidences and computational validation on bioactivity of Distichochlamys citrea M.F. Newman rhizome n-hexane extract against Streptococcus pyogenes were carried out. Experiments found twenty-one bioactive components in the n-hexane extract, which altogether exhibits an overall antibiotic activity of significance against the bacterium; Computations suggested a mechanism based on inhibition of S-ribosylhomocysteine lyase structure. Its biocompatibility and pharmacology were also predicted.