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- Anh-Tuan Le (14)
- Quan-Hoang Vuong (14)
- Ngo, Xuan Dinh (11)
- Tuan Q. Do (10)
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Venomous snake bite is common poisonous accident and important medical problem around the world. The snake anti-venom is only type-specific protection to each venom type that was used to immunize. In this study, the chicken egg yolk (IgY) antibodies against the Vietnamese cobra Naja Naja venom was developed and evaluated in in-vitro (ELISA and SDS-PAGE) and in-vivo (hen and mice immunization). In particularly, the LD50 of the Vietnamese cobra Naja Naja venom was determined at 1.46 g kg−1 body weight of the Swiss mice. The ISA Brown layers of 16 to 18-week-old were immunized intramuscularly with the Vietnamese cobra Naja Naja venom at 0.5 mg kg−1 body weight of the layers. The specific anti-venom antibodies were presented in both serum and egg yolk at 14 days, reached to highest anti... |
Background
Oral administration is the primary route employed for drug delivery. In addition to the gastrointestinal tract, the oral cavity has been drawing considerable attention owing to its physiological properties and advances in drug carrier development. Notably, nanotechnology has made immense contributions to enhancing drug bioavailability, stability, and efficacy, both in research and clinical settings.
Area covered
The present review comprises lessons from physiological characteristics to fundamental material science knowledge, summarizing the pros and cons of nanotechnology applications in therapeutic drug delivery. The oral cavity presents inherent challenges, including oral cancer, dental caries, oral infection, or oral inflammation, that necessitate local solutions.... |
This paper presents an analytical approach on the nonlinear vibration of nanocomposite multilayer organic solar cell (NMOSC) subjected to the combination of wind load and uniform temperature change. The NMOSC comprises of five layers, which are made of Al, P3HT:PCBM, PEDOT:PSS, Graphene and Glass. Compared to common models of the NMOSC, ITO is replaced by graphene to control the output colors of NMOSC. The nonlinear motion equations and the compatibility equation are deriving by taking into account the effect of viscous damping, von Karman nonlinearity terms, elastic foundations and initial imperfection. The formula of the wind load is improved for consideration in the general case that the direction of the wind load is not just perpendicular to the structure. Four edges of the NMOS... |
Chemo-resistance has pushed cancer treatment to the boundary of failure. This challenge has encouraged scientists to look for nanotechnological solutions. In this study, we have taken this goal one step further without depending on chemotherapy. Specifically, hybrid metal, polymer, and lipid nanoparticles that formed an IR780-a photosensitizer and Zinc copper oxide incorporated nanoparticle (ZCNP) nanoparticles were utilized in a combined photothermal and photodynamic therapy. Through the mediation of triphenylphosphonium (TPP) as a mitochondria-targeting moiety, TPP-conjugated polymer-lipid hybrid nanoparticles containing ZCNP/IR-780 significantly enhanced cellular uptake by cancer cells and selectively targeted the mitochondria, which improved the induction of apoptosis. In tumor-... |
We show that the canonical seesaw mechanism implemented by the
U
(
1
)
B
−
L
gauge symmetry provides two-component dark matter naturally. The seesaw scale that breaks
B
−
L
defines a residual gauge symmetry to be
Z
6
=
Z
2
⊗
Z
3
, where
Z
2
leads to the usual matter parity, while
Z
3
is newly recognized, transforming quark fields nontrivially. The dark matter components—that transform nontrivially under the matter parity and
Z
3
, respectively—can gain arbitrary masses, despite the fact that the
Z
3
dark matter may be heavier than the light quarks
u
,
d
. This dark matter setup can address the XENON1T anomaly recently observed and other observables, given that the dark matter masses are nearly degenerate, heavier than the electron a... |
Ethyl cellulose (EC) is widely used in the pharmaceutical field as a polymeric excipient to fabricate sustained-release drug delivery systems. To develop a controlled release carrier exploiting the unique characteristic acidic environment of the target tumor site, this study examined the use of EC and lecithin (LC) as a nanoparticulated system. Paclitaxel and dihydroartemisinin were used as model drug combinations. The optimized formulated nanoparticles (NPs) of EC (EC NPs) and EC/LC (EC/LC NPs) were spherical and approximately 130 nm in diameter as determined by dynamic light scattering and electron microscopy analyses. The in vitro drug release from EC/LC NPs exhibited a pH-dependent pattern. In in vitro cell studies, the NPs were taken up by cells, and cell growth was inhibited b... |
Threshold switching devices are fundamental active elements in more than Moore approaches, integrating the new generation of non-volatile memory devices. Here, the authors report an in-plane threshold resistive switching device with an on/off ratio above 106, a low resistance state of 10 to 100 kΩ and a high resistance state of 10 to 100 GΩ. Our devices are based on nanocomposites of silver nanowire networks and titanium oxide, where volatile unipolar threshold switching takes place across the gap left by partially spheroidized nanowires. Device reversibility depends on the titanium oxide thickness, while nanowire network density determines the threshold voltage, which can reach as low as 0.16 V. The switching mechanism is explained through percolation between metal–semiconductor is... |
Orange-red-emitting Eu3+-doped Ca9Gd(PO4)7 phosphors have been obtained by a sol-gel technique. These phosphors, excited by UV (270 nm) and near UV light (394 nm), emit orange-red light in the range of 580–710 nm. The Ca9Gd(PO4)7:7 mol% Eu3+ phosphor annealed at 1100 °C shows the highest PL intensity. Judd-Ofelt analysis reveals that the neighbor surroundings of Eu3+ ions are asymmetric, and the lowest asymmetry value is found at the dopant ratio of 7 mol%. The optimal phosphor excited by the wavelength of 394 nm displays an excellent thermal stability (∼76.4 % at 160 °C) with an activation energy of 0.163 eV. The corresponding CIE chromaticity coordinates (x; y) and color purity are calculated to be (0.5849; 0.3635) and 84.6 %, respectively. The quantum efficiency values of the Ca9... |
In magnetic resonance imaging (MRI), the scan time for acquiring an image is relatively long, resulting in patient uncomfortable and error artifacts. Fortunately, the compressed sensing (CS) and parallel magnetic resonance imaging (pMRI) can reduce the scan time of the MRI without significantly compromising the quality of the images. It has been found that the combination of pMRI and CS can better improve the image reconstruction, which will accelerate the speed of MRI acquisition because the number of measurements is much smaller than that by pMRI. In this paper, we propose combining a combined CS method and pMRI for better accelerating the MRI acquisition. In the combined CS method, the under-sampled data of the K-space is performed by taking both regular sampling and traditional ... |
The energy demand has recently been increasing dramatically; thus, it is evident that scientists worldwide need to find out the solution to solve the above problem. Among these technologies, solar and wind power energy are the most potential source as alternatives to fossil fuels. However, these energy sources are not continuous and are therefore considered as additional sources. A regenerative fuel cell (RFC) is a type of fuel cell that can function as an electrolyzer and fuel cell; therefore, this system is an independent power source and overcome the drawbacks of the original fuel cell system. This research has built a system to control the entire regenerative fuel cell system's flow, temperature, and energy. The system uses electricity to produce hydrogen and oxygen for storage;... |
