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Title: | Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples |
Authors: | Huy X. Luong Young-Woo Kim |
Issue Date: | 2020 |
Publisher: | ACS Publications |
Abstract: | Polyproline II helix (PPII) is one of the secondary structures in proteins that play an important role in various biological processes. In this study, we have developed a new macrocyclization strategy that efficiently reinforces a model tetrapeptide into a PPII structure. We also elucidated some relationships between structural features and PPII stability in this model. This new macrocyclic stapling strategy can serve as a useful chemical tool to manipulate the PPII structure for various applications. |
URI: | https://pubs.acs.org/doi/10.1021/acs.orglett.0c02914 https://dlib.phenikaa-uni.edu.vn/handle/PNK/586 |
Appears in Collections | Bài báo khoa học |
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