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    • Shock index as predictor of massive transfusion and mortality in patients with trauma a systematic review and meta-analysis
    Authors: Andrea, Carsetti; Riccardo, Antolini; Erika, Casarotta;  Advisor: -;  Co-Author: - (2023)

    Management of bleeding trauma patients is still a difficult challenge. Massive transfusion (MT) requires resources to ensure the safety and timely delivery of blood products. Early prediction of MT need may be useful to shorten the time process of blood product preparation. The primary aim of this study was to assess the accuracy of shock index to predict the need for MT in adult patients with trauma. For the same population, we also assessed the accuracy of SI to predict mortality.
    • Outcomes of intravenous and inhalation anesthesia on patients undergoing esophageal cancer surgery: a retrospective observational study
    Authors: Yue, Ma; Jie, Ren; Zhuo, Chen;  Advisor: -;  Co-Author: - (2023)

    Different anesthetics may have opposite effects on the immune system, thus affecting the prognosis of tumor patients. Cell-mediated immunity forms the primary defense against the invasion of tumor cells, so manipulation of the immune system to produce an enhanced anti-tumor response could be utilized as an adjuvant oncological therapy. Sevoflurane has proinflammatory effects, while propofol, has anti-inflammatory and antioxidant effects. Therefore, we compared the overall survival (OS) and disease-free survival (DFS) of patients with esophageal cancer under total intravenous anesthesia and inhalation anesthesia.
    • The cytokine adsorber Cytosorb® does not reduce ammonia concentrations in critically ill patients with liver failure
    Authors: Uwe, Liebchen; Michael, Paal; Caroline, Gräfe;  Advisor: -;  Co-Author: - (2023)

    Hemadsorption techniques are used in critical care for numerous indications, although the evidence is often limited. One example is the elimination of ammonia with the cytokine adsorber Cytosorb® (adsorption based on hydrophobic interactions of substances with a molecular weight of 5–55 kDa). Most recently, in vitro and in vivo data postulated that Cytosorb® (combined with continuous kidney replacement therapy (CKRT)) could eliminate ammonia [1, 2].
    • Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
    Authors: Syed M. T., Nasser; Anas A., Rana; Rainer, Doffinger;  Advisor: -;  Co-Author: - (2023)

    Divergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophage Activation Syndrome, which can be driven by elevated Free Interleukin-18 (IL-18) due to failure of negative-feedback release of IL-18 binding protein (IL-18bp). We, therefore, designed a prospective, longitudinal cohort study to examine IL-18 negative-feedback control in relation to COVID-19 severity and mortality from symptom day 15 onwards.
    • Plasma bioactive adrenomedullin on intensive care unit admission is associated with acute respiratory distress syndrome: an observational study
    Authors: Patrik, Johnsson; Andrea, Fredriksson; Christer, Tung;  Advisor: -;  Co-Author: - (2023)

    Bioactive adrenomedullin (bio-ADM) is a vasoactive peptide with a key role in reducing vascular hyperpermeability and improving endothelial stability during infection, but it also has vasodilatory properties. Bioactive ADM has not been studied in conjunction with acute respiratory distress syndrome (ARDS), but it has recently been shown to correlate with outcomes after severe COVID-19. Therefore, this study investigated the association between circulating bio-ADM on intensive care unit (ICU) admission and ARDS. The secondary aim was the association between bio-ADM and ARDS mortality.
    • Primary diffuse Rosai-Dorfman disease in central airway a case report and literature review
    Authors: Lei, Wu; Yan, Zhang; Xiaoya, Guo;  Advisor: -;  Co-Author: - (2023)

    Rosai-Dorfman disease (RDD) is a rare benign non-langerhans cell histiocytosis, mainly involving lymph nodes and skin. It is even rarer occurring only in central airway of lung and in diffuse form. Central airway RDD is similar to malignant tumor in imaging by radiological method and in bronchoscopy features. It is difficult to differentiate it from primary airway malignant tumor and to diagnose correctively in time.