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dc.contributor.authorYupei, Li-
dc.contributor.authorYu, Chen-
dc.contributor.authorTinghang, Yang-
dc.date.accessioned2023-03-20T08:24:56Z-
dc.date.available2023-03-20T08:24:56Z-
dc.date.issued2023-
dc.identifier.urihttps://link.springer.com/article/10.1186/s13054-023-04382-0-
dc.identifier.urihttps://dlib.phenikaa-uni.edu.vn/handle/PNK/6995-
dc.descriptionCC BYvi
dc.description.abstractBoth high mobility group box-1 (HMGB1) and histones are major damage-associated molecular patterns (DAPMs) that mediate lethal systemic inflammation, activation of the complement and coagulation system, endothelial injury and multiple organ dysfunction syndrome in critical illnesses. Although accumulating evidence collectively shows that targeting HMGB1 or histones by their specific antibodies or inhibitors could significantly mitigate aberrant immune responses in multiple critically ill animal models, routine clinical use of such agents is still not recommended by any guideline.vi
dc.language.isoenvi
dc.publisherSpringervi
dc.subjecthigh mobility group box-1vi
dc.subjectdamage-associated molecular patternsvi
dc.titleTargeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnessesvi
dc.typeBookvi
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