Thông tin tài liệu
Nhan đề : |
Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses |
Tác giả : |
Yupei, Li Yu, Chen Tinghang, Yang |
Năm xuất bản : |
2023 |
Nhà xuất bản : |
Springer |
Tóm tắt : |
Both high mobility group box-1 (HMGB1) and histones are major damage-associated molecular patterns (DAPMs) that mediate lethal systemic inflammation, activation of the complement and coagulation system, endothelial injury and multiple organ dysfunction syndrome in critical illnesses. Although accumulating evidence collectively shows that targeting HMGB1 or histones by their specific antibodies or inhibitors could significantly mitigate aberrant immune responses in multiple critically ill animal models, routine clinical use of such agents is still not recommended by any guideline. |
Mô tả: |
CC BY |
URI: |
https://link.springer.com/article/10.1186/s13054-023-04382-0 https://dlib.phenikaa-uni.edu.vn/handle/PNK/6995 |
Bộ sưu tập |
OER- Y học- Điều dưỡng |
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