Thông tin tài liệu
Nhan đề : |
Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study |
Tác giả : |
Lucy A., Coupland David J., Rabbolini Jonathan G., Schoenecker |
Năm xuất bản : |
2023 |
Nhà xuất bản : |
Springer |
Tóm tắt : |
ibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g. sepsis, acute respiratory failure (ARF) and trauma, the fibrinolytic response is reduced and may lead to widespread thrombosis and multi-organ failure. The mechanisms underpinning fibrinolysis resistance include reduced t-PA expression and/or release, reduced t-PA and/or plasmin effect due to elevated inhibitor levels, increased consumption and/or clearance. This study in critically ill patients with fibrinolysis resistance aimed to evaluate the ability of t-PA and plasminogen supplementation to restore fibrinolysis with assessment using point-of-care ClotPro viscoelastic testing (VET). |
Mô tả: |
CC BY |
URI: |
https://link.springer.com/article/10.1186/s13054-023-04329-5 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7078 |
Bộ sưu tập |
OER- Y học- Điều dưỡng |
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