Item Infomation


Title: 
Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine
Authors: 
Zheng, Xie
Aaron P., Fox
Issue Date: 
2023
Publisher: 
Springer
Abstract: 
The α2 adrenergic receptor agonist dexmedetomidine is an important intravenous sedative with analgesic properties. Currently available dexmedetomidine reversal agents, like the α2-receptor antagonist atipamezole, cause serious adverse effects at the large dosages required for effective reversal; they are not used clinically. Without reversal agents, emergence times from dexmedetomidine sedation are slow. In this study we tested the ability of low-dose atipamezole, in combination with caffeine, to reverse dexmedetomidine sedation. The low dose of atipamezole employed should not be associated with unwanted effects.
Description: 
CC BY
URI: 
https://link.springer.com/article/10.1186/s12871-023-01986-5
https://dlib.phenikaa-uni.edu.vn/handle/PNK/7180
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