A well-known but rarely seen interaction: propofol with lignocaine

Abstract

Propofol is considered an excellent intravenous anesthetic agent. However, a 30–70% incidence of pain associated with its injection is a significant source of patient discontent. Injection pain and discomfort rank as the sixth most crucial perioperative issue (Desousa 2016). Several techniques have been employed to reduce injection discomfort, including the use of the forearm and antecubital veins, freezing or warming the injectate, and aspirating blood before injection. Pre-treatment or contemporaneous administration of thiopentone, pethidine, fentanyl, dexamethasone, nitroglycerine, ketorolac, and local anesthetics has also been considered.