Item Infomation
Title: | Macrophage Anti-inflammatory Behaviour in a Multiphase Model of Atherosclerotic Plaque Development |
Authors: | Ishraq U., Ahmed Helen M., Byrne Mary R., Myerscough |
Issue Date: | 2023 |
Publisher: | Springer |
Abstract: | Atherosclerosis is an inflammatory disease characterised by the formation of plaques, which are deposits of lipids and cholesterol-laden macrophages that form in the artery wall. The inflammation is often non-resolving, due in large part to changes in normal macrophage anti-inflammatory behaviour that are induced by the toxic plaque microenvironment. These changes include higher death rates, defective efferocytic uptake of dead cells, and reduced rates of emigration. We develop a free boundary multiphase model for early atherosclerotic plaques, and we use it to investigate the effects of impaired macrophage anti-inflammatory behaviour on plaque structure and growth. |
Description: | CC BY |
URI: | https://link.springer.com/article/10.1007/s11538-023-01142-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7479 |
Appears in Collections | OER - Khoa học Tự nhiên |
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