Spent coffee ground (SCG) is a primary by-product obtained during soluble coffee processing and could be used for high-value products due to its protein content. The SCG is a rich source of cellulose, hemicellulose, lignin, lipids and proteins. The bioactive peptide obtained after protein hydrolysis has great potential as an antioxidant, antimicrobial, and anti-mutagenic agent and a better understanding is a prerequisite for proper utilization of the natural and renewable source of protein to attain a sustainable approach. Moreover, by utilizing SCG-derived peptides we can reduce the contamination of these residues at an agronomical scale. In this review, we discussed the spent coffee ground protein-based peptides and also high-lightened the properties of these valuable bioactive pe...