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- Manyk, T. (3)
- Murawski, K. (3)
- Baumgartner, Jörg (2)
- Guizani, Chamseddine (2)
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Date issued
- 2023 (187)
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The IIW-Recommendation for fatigue design of welded joints and components presents two different evaluation approaches for multiaxial stress states under constant amplitude: an approach based on the maximum principal stress, which is only applicable under certain conditions, and the Gough-Pollard approach for the remaining cases. In the course of this work, this maximum principal stress-based approach is analyzed. It is examined in which cases the method is applicable, the advantages and disadvantages compared to the approach according to Gough-Pollard are discussed, and an evaluation according to the von Mises equivalent stress is presented as a third alternative. This is followed by a validation based on literature data on laser-welded steel joints using the nominal stress, hot sp... |
To clarify the effect of solution heat-treatment on the oxidation resistance of Ni-base single-crystal superalloy TMS-238, the evaluation of dendrite/inter-dendrite segregation of alloying elements in the as-cast and heat-treated samples, and its effect on cyclic oxidation resistance were investigated. Cyclic oxidation test results at 1100 °C for up to 150 cycles clearly showed that the as-cast samples with element segregations had lower oxidation resistance compared to heat-treated samples with homogeneous structure. Further, for the as-cast sample, rapid growth and spallation of oxide consisting of NiO, Cr2O3, and Al2O3 were observed around the dendrite core for 10 cycles of oxidation. |
In recent years, cardiovascular disease in particular myocardial infarction (MI) has become the predominant cause of human disability and mortality in the clinical setting. The restricted capacity of adult cardiomyocytes to proliferate and restore the function of infarcted sites is a challenging issue after the occurrence of MI. The application of stem cells and byproducts such as exosomes (Exos) has paved the way for the alleviation of cardiac tissue injury along with conventional medications in clinics. However, the short lifespan and activation of alloreactive immune cells in response to Exos and stem cells are the main issues in patients with MI. Therefore, there is an urgent demand to develop therapeutic approaches with minimum invasion for the restoration of cardiac function.<... |
he effect of the thickness of a multilayer TiO2 photoanode on the performance of a dye-sensitized solar cell (DSC) made with a polyethylene oxide-based gel polymer electrolyte containing ternary iodides and performance enhancer 4-tert-butylpyridine is studied. Multilayer photoanodes consisting of up to seven layers of TiO2 nano-particles (13 nm and 21 nm) are prepared by spin coating of successive layers. XRD results confirm the predominant presence of the anatase phase of TiO2 in the multilayer structure after sintering. The SEM images reveal the formation of a single TiO2 film upon sintering due to merging of individually deposited layers. The photocurrent density (JSC) and the efficiency increase with the number of TiO2 layers exhibiting the maximum efficiency and JSC of 5.5% and... |
The global effects of MP (MP) pollution on the environment are concerning, and they are exacerbated by the multiple sources of pollution in aquatic environments such as urban runoff, waste mismanagement, industrial pollution, and so on. South pacific islands host a large diversity of aquatic flora and fauna and given its ecological significance it is necessary to identify the sources of MP pollution in the region. To date, very little attention has been given to identify whether effluents from wastewater treatment plants (WWTP) are acting as a significant source of MP in the South Pacific region and its countries. Therefore, the present study analyzed and compared the treatment methods and fate of MPs in the country’s two main WWTPs: 1) the Kinoya WWTP (simple secondary clarifier an... |
Bee pollen extract (BPE)-based polymer nanoparticles (BPENP) were fabricated using bovine serum albumin (BSA) and targeted with folic acid and were further characterized. Mice groups are: Group 1 received saline, whereas Groups 2, 3, 4, 5, and 6 received a single dose of urethane, followed by weekly injections of butylated hydroxy-toluene (BHT). After the BHT injection, the mice in Groups 3, 4, 5, and 6 received BPE, Avastin, BPENP, and BPENP + Avastin, respectively. The number and size of tumors were decreased in Group 6 compared to those in the other groups. The ratios of early and late apoptotic cells in Groups 3, 4, 5, and 6 (42.8%, 41.4%, 26.2%, and 45.4%, respectively) were higher than that in the untreated group. The PCNA-labeling indexes (LI)% in tissues and lesions from Gro... |
High-temperature oxidation behavior of conventionally cast and additively manufactured (AM) Co-base alloy MAR-M-509 was compared in the present study. The specimens were exposed in air at 1000 °C and characterized by means of scanning electron microscopy equipped with energy/wavelength dispersive x-ray spectroscopy (EDX/WDX) and electron backscatter diffraction as well as transmission electron microscopy. Substantial differences in the oxidation processes of two alloy versions were observed. Faster oxidation of the cast alloy was mainly induced by (1) oxidation of coarse primary carbides, (2) internal oxidation and nitridation processes and (3) incorporation of other alloy constituents (e.g., Co, Ni, W) into the Cr-oxide scale. AM specimens, in contrast, formed a more homogeneous, t... |
PEGylated nanoparticles (PEG-NPs) are not effective for hematologic malignancies as they lack the enhanced permeability and retention effect (EPR effect). Tumor-targeted PEG-NPs can systemically track lymphoma and actively internalize into cancer cells to enhance therapeutic efficacy. We generated an anti-PEG bispecific antibody (BsAb; mPEG × CD20) which was able to simultaneously bind to methoxy PEG on liposomes and CD20 to form multivalent αCD20-armed liposomes. This αCD20-armed liposome was able to crosslink CD20 on lymphoma cells to enhance cellular internalization and the anti-cancer efficacy of the liposomes to lymphoma. We generated mPEG × CD20 and used this bispecific antibody to modify PEGylated liposomal doxorubicin (PLD) through a one-step formulation. |
Alzheimer’s disease is a neurodegenerative disorder, and Aβ aggregation is considered to be the central process implicated in its pathogenesis. Current treatments are faced by challenges such as serious side effects and reduced drug bioavailability. In this study, we developed a drug delivery system for intramuscular injection that uses cellular activity to achieve constant and long-term drug release. |
Endometriosis is a common gynecological disease in women of childbearing age. Commonly used treatment methods, such as endocrine and surgical therapies, display poor therapeutic effects with a high relapse probability. Thus, novel treatments for endometriosis are required. |
