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Title: | Based polymer nanoparticles from bee pollen attenuate non-small lung cancer through enhancement of apoptosis and cell cycle arrest in vivo |
Authors: | Salim, Elsayed I. Mahfouz, Magdy E. Eltonouby, Eman A. |
Issue Date: | 2023 |
Publisher: | Springer |
Abstract: | Bee pollen extract (BPE)-based polymer nanoparticles (BPENP) were fabricated using bovine serum albumin (BSA) and targeted with folic acid and were further characterized. Mice groups are: Group 1 received saline, whereas Groups 2, 3, 4, 5, and 6 received a single dose of urethane, followed by weekly injections of butylated hydroxy-toluene (BHT). After the BHT injection, the mice in Groups 3, 4, 5, and 6 received BPE, Avastin, BPENP, and BPENP + Avastin, respectively. The number and size of tumors were decreased in Group 6 compared to those in the other groups. The ratios of early and late apoptotic cells in Groups 3, 4, 5, and 6 (42.8%, 41.4%, 26.2%, and 45.4%, respectively) were higher than that in the untreated group. The PCNA-labeling indexes (LI)% in tissues and lesions from Group 6 were lower than those in the other groups; on the other hand, the Caspase-3 LI (%) was higher than those in the other groups. |
Description: | CC-BY |
URI: | https://link.springer.com/article/10.1186/s12645-023-00229-z https://dlib.phenikaa-uni.edu.vn/handle/PNK/9508 |
Appears in Collections | OER - Khoa học Vật liệu, Ứng dụng |
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