Search

Current filters:

Current filters:

Author

Subject

Date issued

Has File(s)

Search Results

Results 1-1 of 1 (Search time: 0.001 seconds).
  • <<
  • 1
  • >>
    • In vitro and in vivo toxicity of carbon dots with different chemical compositions
    Authors: Kuznietsova, Halyna; Géloën, Alain; Dziubenko, Nataliia;  Advisor: -;  Co-Author: - (2023)

    Carbon dots (CDs) are easy-obtained nanoparticles with wide range of biological activity; however, their toxicity after prolonged exposure is poorly investigated. So, in vitro and in vivo toxicity of CDs with the surfaces enriched with hydroxylated hydrocarbon chains and methylene groups (CD_GE), carboxyl and phenol groups accompanied with nitrogen (CD_3011), trifluoromethyl (CDF19) or toluidine and aniline groups (CDN19) were aimed to be discovered. CDs’ in vitro toxicity was assessed on A549 cells (real-time cell analysis of impedance, fluorescence microscopy) after 24 h of incubation, and we observed no changes in cell viability and morphology. CDs’ in vivo toxicity was assessed on C57Bl6 mice after multiple dosages (5 mg/kg subcutaneously) for 14 days.