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Title: In vitro and in vivo toxicity of carbon dots with different chemical compositions
Authors: Kuznietsova, Halyna
Géloën, Alain
Dziubenko, Nataliia
Issue Date: 2023
Publisher: Springer
Abstract: Carbon dots (CDs) are easy-obtained nanoparticles with wide range of biological activity; however, their toxicity after prolonged exposure is poorly investigated. So, in vitro and in vivo toxicity of CDs with the surfaces enriched with hydroxylated hydrocarbon chains and methylene groups (CD_GE), carboxyl and phenol groups accompanied with nitrogen (CD_3011), trifluoromethyl (CDF19) or toluidine and aniline groups (CDN19) were aimed to be discovered. CDs’ in vitro toxicity was assessed on A549 cells (real-time cell analysis of impedance, fluorescence microscopy) after 24 h of incubation, and we observed no changes in cell viability and morphology. CDs’ in vivo toxicity was assessed on C57Bl6 mice after multiple dosages (5 mg/kg subcutaneously) for 14 days.
Description: CC-BY
URI: https://link.springer.com/article/10.1186/s11671-023-03891-9
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9027
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