Item Infomation


Title: 
Iron oxide polyaniline-coated nanoparticles modulate tumor microenvironment in breast cancer: an in vitro study on the reprogramming of tumor-associated macrophages
Authors: 
Nascimento, Camila Sales
Tavares, Naiara Clemente
Batista, Izabella Cristina Andrade
Issue Date: 
2023
Publisher: 
Springer
Abstract: 
Breast cancer is the neoplastic disease with the highest incidence and mortality in the female population worldwide. Treatment remains challenging due to various factors. Therefore, it is of great importance to develop new therapeutic strategies that promote the safe destruction of neoplastic cells without compromising patients' quality of life. Among advances in the treatment of breast cancer, immunotherapy stands out as a promising trend. Recent studies have demonstrated the potential of iron oxide nanoparticles in promoting the reprogramming of M2 macrophages (pro-tumor phenotype) into M1 macrophages (anti-tumor phenotype) within the tumor microenvironment, resulting in potent antitumor effects. In this study, the effect of polyaniline-coated iron oxide nanoparticles (Pani/y-Fe2O3) on macrophage polarization and breast cancer cell death was investigated.
Description: 
CC-BY
URI: 
https://link.springer.com/article/10.1186/s12645-023-00225-3
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9035
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