Thông tin tài liệu
Nhan đề : | Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers |
Tác giả : | Salel, Sedef Iyisan, Banu |
Năm xuất bản : | 2023 |
Nhà xuất bản : | Springer |
Tóm tắt : | Nanocarrier systems are widely used for drug delivery applications, but limitations such as the use of synthetic surfactants, leakage of toxic drugs, and a poor encapsulation capacity remain as challenges. We present a new hybrid nanocarrier system that utilizes natural materials to overcome these limitations and improve the safety and efficacy of drug delivery. The system comprises a biopolymeric shell and a lipid core, encapsulating the lipophilic anticancer drug paclitaxel. Bovine serum albumin and dextran, in various molecular weights, are covalently conjugated via Maillard reaction to form the shell which serves as a stabilizer to maintain nanoparticle integrity. The properties of the system, such as Maillard conjugate concentration, protein/polysaccharide molar ratio, and polysaccharide molecular weight, are optimized to enhance nanoparticle size and stability. |
Mô tả: | CC-BY |
URI: | https://link.springer.com/article/10.1186/s11671-023-03897-3 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9060 |
Bộ sưu tập | OER - Khoa học Vật liệu, Ứng dụng |
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