Tìm kiếm
Tác giả
- Anh-Tuan Le (12)
- Ngo, Xuan Dinh (10)
- Quan-Hoang Vuong (8)
- Truong V. Vu (8)
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Chủ đề
- Molecular dynamics (3)
- Nanoparticles (3)
- Parallel robot (3)
- Physical Chemistry (3)
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Kết quả tìm kiếm
In our continuing search for novel small‐molecule anticancer agents, we designedand synthesized a series of novel (E)‐N'‐(3‐allyl‐2‐hydroxy)benzylidene‐2‐(4‐oxoquinazolin‐3(4H)‐yl)acetohydrazides (5), focusing on the modification of sub-stitution in the quinazolin‐4(3H)‐one moiety. The biological evaluation showed thatall 13 designed and synthesized compounds displayed significant cytotoxicity againstthree human cancer cell lines (SW620, colon cancer; PC‐3, prostate cancer; NCI‐H23, lung cancer). The most potent compound5ldisplayed cytotoxicity up to 213‐fold more potent than 5‐fluorouracil and 87‐fold more potent than PAC‐1, the firstprocaspase‐activating compound. Structure–activity relationship analysis revealedthat substitution of either electron‐withdrawing or electron‐releas... |
Compound and simple droplets have been studied and appeared in many life applications, e.g., drug processing and microfluidic systems. Many studies have been conducted on the thermocapillary effects on simple droplets, but similar studies on compound droplets are quite rare. Filling this missing gap, this paper presents the front-tracking-based simulation results of the thermocapillary effects on compound droplets in a certain limited domain. The compound droplet consists of a single inner core that is initially concentric with the outer one. Various dimensionless parameters including Reynolds number from 1 to 50, Marangoni number from 1 to 100, droplet radius ratio from 0.3 to 0.8, and viscosity ratios from 0.1 to 6.4 are varied to reveal their influences on the migration of a comp... |
Haptic devices had known as advanced technology with the goal is creating the experiences of touch by applying forces and motions to the operator based on force feedback. Especially in unmanned aerial vehicle (UAV) applications, the position of the end-effector Falcon haptic sets the velocity command for the UAV. And the operator can feel the experience vibration of the vehicle as to the acceleration or collision with other objects through a forces feedback to the haptic device. In some emergency cases, the haptic can report to the user the dangerous situation of the UAV by changing the position of the end-effector which is be obtained by changing the angle of the motor using the inverse kinematic equation. But this solution may not accurate due to the disturbance of the system. The... |
Modern society has been facing serious health-related problems including food safety, diseases and illness. Hence, it is urgent to develop analysis methods for the detection and control of food contaminants, disease biomarkers and pathogens. As the traditional instrumental methods have several disadvantages, including being time consuming, and having high cost and laborious procedures, optical nanosensors have emerged as promising alternative or complementary approaches to those traditional ones. With the advantages of simple preparation, high surface-to-volume ratio, excellent biocompatibility, and especially, unique optical properties, gold nanoparticles (AuNPs) have been demonstrated as excellent transducers for optical sensing systems. |
Although most Asian states are signatories to UNCLOS, which offers options for dispute resolution by either voluntary or compulsory processes, in reality fewer than a dozen Asian states have taken advantage of such an approach. The decision to adopt third-party mechanisms comes under great scrutiny and deliberation, not least because of the entailing legal procedures and the politically sensitive nature of disputes. Vietnam claims the second-largest maritime area in the South China Sea dispute after China. A comparison of two recent cases—the arbitration between the Philippines and China and the conciliation between Timor-Leste and Australia—highlights the importance of selecting between binding and nonbinding decisions and framing a complaint. In particular, any legal action under ... |
Transparent electrodes (TEs) are pivotal components in many modern devices such as solar cells, light-emitting diodes, touch screens, wearable electronic devices, smart windows, and transparent heaters. Recently, the high demand for flexibility and low cost in TEs requires a new class of transparent conductive materials (TCMs), serving as substitutes for the conventional indium tin oxide (ITO). So far, ITO has been the most used TCM despite its brittleness and high cost. Among the different emerging alternative materials to ITO, metallic nanomaterials have received much interest due to their remarkable optical-electrical properties, low cost, ease of manufacturing, flexibility, and widespread applicability. These involve metal grids, thin oxide/metal/oxide multilayers, metal nanowir... |
Affective computing, also known as emotional artificial intelligence (AI), is an emerging and cutting-edge field of AI research. It draws on computer science, engineering, psychology, physiology, and neuroscience to computationally model, track, and classify human emotions and affective states. While the US once dominated the field in terms of research and citation from 1995–2015, China is now emerging as a global contender in research output, claiming second place for the most cited country from 2016–2020. This article maps the rhizomatic growth and development of scientific publications devoted to emotion-sensing AI technologies. It employs a bibliometric analysis that identifies major national contributors and international alliances in the field over the past 25 years. |
To date, a very limited number of peptides reported as quorum sensing inhibitors. Herein, we report the synthesis and evaluation of a series of β-turn mimetic-based peptides as potent quorum sensing inhibitors and antibiofilm formation. In this series, peptides P1, P4, and P5 showed very promising anti-quorum sensing activity on lasB-gfp reporter strain of Pseudomonas aeruginosa without affecting bacterial growth. Under our condition, these compounds also showed good anti-violacein production of Chromobacterium violaceum. In terms of antibiofilm formation, except P5, two β-turn mimetic-based peptides P1 and P4 showed maximum inhibition of 80% total biomass of Pseudomonas aeruginosa. This report provides the first β-turn mimetic-based scaffold for future drug development. |
We have proposed a fruitful design principle targeting a concentration ratio (CR) >1000× for a typical high concentrating photovoltaics (HCPV) system, on account of a two-concentrator system + homogenizer. The principle of a primary dual-lens concentrator unit, completely analogous basic optics seen in the superposition compound eyes, is a trend not hitherto reported for solar concentrators to our knowledge. Such a concentrator unit, consisting of two aspherical lenses, can be applied to minify the sunlight and reveal useful effects. We underline that, at this stage, the CR can be attained by two orders of magnitude simply by varying the radius ratio of such two lenses known from the optics side. The output beam is spatially minimized and nearly parallel, exactly as occurs in the su... |
The molecular dynamics simulations have been carried out to investigate the mechanical behaviors of amorphous silicon nitride under the uniaxial tensile deformation. The amorphous silicon nitride was obtained by the cooling process. The network structure of the sample consists of SiNx (x = 3, 4 and 5) units and NSiy (y = 2, 3 and 4) linkages. The stress-strain curve of the sample exhibits the elastic and plastic deformation. The Si-N bond lengths are stretched out in the elastic region and the plastic region I. They are shrunk to the initial state in the plastic region II due to the appearance of the large clusters which contain the overlapping big simplexes with the RS ≥ 2.4 Å. These big simplexes tend to appear at the shear transformation zones in the elastic region. These shear t... |
