Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock a double-blind, randomized, placebo-controlled trial

Abstract

Intravenous CYT107 reversed sepsis-induced lymphopenia. However, compared to intramuscular CYT107 administration, it was associated with transient respiratory distress without long-term sequelae. Because of equivalent positive laboratory and clinical responses, more favorable pharmacokinetics, and better patient tolerability, intramuscular administration of CYT107 is preferable.