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A biological evaluation revealed that all thirteen compounds designed and synthesized showed strong cytotoxicity against three human cancer cell lines (SW620, colon cancer; PC-3, prostate cancer; NCI-H23, lung cancer) with eight compounds (5a, 5c-i, 5k), which were clearly more potent than both PAC-1 and oncrasin-1. In this series, four compounds, including 5c, 5e, 5f, and 5h, were the most potent members with approximately 4- to 5-fold stronger than the reference compounds PAC-1 and oncrasin-1 in terms of IC50. In comparison to 5-FU, these compounds were even 18- to 29-fold more potent in terms of cytotoxicity in three human cell lines tested. In the caspase activation assay, the caspase activity was activated to 285% by compound 5e compared to PAC-1, the first procaspase activatin... |
We present a supermassive black hole (SMBH) mass measurement in the Seyfert 1 galaxy NGC 7469 using Atacama Large Millimeter/submillimeter Array (ALMA) observations of the atomic-[CI](1–0) and molecular-12CO(1–0) emission lines at the spatial resolution o |
Traditionally, students from the Southern world tend to cross their national borders to study abroad. However, in recent times, we have observed a trend in which more and more students, both full-time and short-term, select Southern countries as destinations for overseas education. This paper contributes to the sparse literature on the above phenomenon, examining the case of Vietnam. We surveyed 50 universities and colleges about their international student profiles (including statistics and nationalities) and their strategies for attracting international students. The findings of this study provide implications for Vietnam's policymakers and university/college leaders and other Southern countries when implementing the internationalization of tertiary education. |
Haptic devices had known as advanced technology with the goal is creating the experiences of touch by applying forces and motions to the operator based on force feedback. Especially in unmanned aerial vehicle (UAV) applications, the position of the end-effector Falcon haptic sets the velocity command for the UAV. And the operator can feel the experience vibration of the vehicle as to the acceleration or collision with other objects through a forces feedback to the haptic device. In some emergency cases, the haptic can report to the user the dangerous situation of the UAV by changing the position of the end-effector which is be obtained by changing the angle of the motor using the inverse kinematic equation. But this solution may not accurate due to the disturbance of the system. The... |
This paper concerns the staffing optimization problem in multi-skill call centers. The objective is to find a minimal cost staffing solution while meeting a target level for the quality of service (QoS) to customers. We consider a staffing problem in which joint chance constraints are imposed on the QoS of the day. Our joint chance-constrained formulation is more rational capturing the correlation between different call types, as compared to separate chance-constrained versions considered in previous studies. We show that, in general, the probability functions in the joint-chance constraints display S-shaped curves, and the optimal solutions should belong to the concave regions of the curves. Thus, we propose an approach combining a heuristic phase to identify solutions lying in the... |
The COVID-19 pandemic has disrupted the lives of many. Particularly, nursing students experience greater stress as their normal curriculum is interrupted and some of them face the risk of being infected as frontline workers. Nursing faculty members may face similar struggles, in addition to developing teaching materials for online learning. Thus, it is important to examine the faculty members' and students' views on their ability to adapt during the pandemic to obtain a holistic view of how learning and training has been affected |
In this paper, we extend a recent proposed model of two scalar and two vector fields to a hyperbolic inflation scenario, in which the field space of two scalar fields is a hyperbolic space instead of a flat space. In this model, one of the scalar fields is assumed to be a radial field, while the other is set as an angular field. Furthermore, both scalar fields will be coupled to two different vector fields, respectively. As a result, we are able to obtain a set of exact Bianchi type I solutions to this model. Stability analysis is also performed to show that this set of anisotropic solutions is indeed stable and attractive during the inflationary phase. This result indicates that the cosmic no-hair conjecture is extensively violated in this anisotropic hyperbolic inflation model |
Three major scientific policies implemented in 2008, 2014, and 2017 have pushed Vietnam’s social sciences and humanities (SSH) toward higher international standards. This study uses descriptive and Bayesian approaches on a dataset of 1,564 Vietnamese authors in the 2008–18 period to understand the changes under the new policies and the remaining challenges. The findings indicate that Economics is the most productive SSH field, with 858 publications in 11 years. Even though the number of authors has risen rapidly, gender disparity is still an issue. Economics has benefitted the most from Vietnam's development, and to a lesser extent, so have Education and Social Medicine. Future policies should aim to provide an enabling environment for female and early career researchers in every SS... |
Recently, Asia has emerged as a new hub of international students, apart from the traditional hosts such as North America, Europe or Australia. Along with this phenomenon, there has been increasing international education scholars selecting international student mobilities in Asia as objects of research. Nevertheless, there has not yet any systematic knowledge about the existing literature on international student mobilities in Asia-related studies. This project aims to fulfil this void by analyzing data obtained from Scopus dataset from 1984 to 2019. Using descriptive statistics as well as advanced bibliometric analyses, the review identified influential documents, topics, sources whose impact has been sustained for several decades. The review also identified prominent authors and ... |
Serpentinite-derived soils are characterized by low Ca/Mg ratio and abnormally high Cr and Ni concentrations due to the geogenic sources. The breakdown of parent materials during pedogenesis may lead to the changes in both Ca/Mg ratios and fractions of Cr and Ni. This study hypothesized that total Ca/Mg (Cat/Mgt) and exchangeable Ca/Mg (Cae/Mge) ratios increase with soil development, associated with the increases in potentially mobile fractions (PMFs) of Cr and Ni. Thirty-five soil horizon samples of eight pedons from Japan, Taiwan, Philippines, and Vietnam were collected, and the exchangeable concentrations of Ca and Mg were measured. |
